Mechanisms Underlying Mechanical Dysfunction After Rewarming From Hypothermia
نویسندگان
چکیده
منابع مشابه
Mechanisms underlying hypothermia-induced cardiac contractile dysfunction.
Rewarming patients after profound hypothermia may result in acute heart failure and high mortality (50-80%). However, the underlying pathophysiological mechanisms are largely unknown. We characterized cardiac contractile function in the temperature range of 15-30 degrees C by measuring the intracellular Ca(2+) concentration ([Ca(2+)](i)) and twitch force in intact left ventricular rat papillary...
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Although accidental hypothermia is considered a totally preventable cause of death, severe hypothermia (<28 o C) carries a mortality rate about 21%. That’s why conventional rewarming techniques such as using a warming blanket, warm intravenous saline, nasogastric lavage, continuous bladder irrigation and thoracic lavage via chest tubes are often considered inefficient and extracorporeal circula...
متن کاملLeft ventricular dysfunction following rewarming from experimental hypothermia.
This study was aimed at elucidating whether ventricular hypothermia-induced dysfunction persisting after rewarming the unsupported in situ dog heart could be characterized as a systolic, diastolic, or combined disturbance. Core temperature of 8 mongrel dogs was gradually lowered to 25 degreesC and returned to 37 degreesC over a period of 328 min. Systolic function was described by maximum rate ...
متن کاملBath rewarming from immersion hypothermia.
Trunk-only bath rewarming has often been recommended over whole-body bath rewarming as a method for the treatment of immersion hypothermia. At present, no report of a direct comparison of the relative merits of these techniques has been made. Authorities in favor of trunk-only bath rewarming base their proposal on the assumption that core temperature afterdrop would be minimized by preventing p...
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OBJECTIVES The aim of this study was to simultaneously analyze the key components of the cerebral and systemic inflammatory response over time in cardiac arrest patients during mild therapeutic hypothermia and rewarming. DESIGN AND SETTING Clinical observational study in a tertiary care university hospital. PATIENTS Ten comatose patients after out-of-hospital cardiac arrest. INTERVENTIONS...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.953.14